منابع مشابه
Dehydroepiandrosterone replacement therapy.
Dehydroepiandrosterone (DHEA) and its sulphated derivative DHEAS are the most abundant circulating steroids, and are derived from the zona reticularis of the adrenal cortex. The foetal adrenals synthesise signi®cant quantities of DHEA, but production of this steroid falls postnatally. The onset of adrenarche (between the ages of 6 and 8 years) is characterised by increasing biosynthesis of DHEA...
متن کاملDehydroepiandrosterone replacement for patients with adrenal insufficiency.
10 Auwerx J. PPAR , the ultimate thrifty gene. Diabetologia 1999; 42: 1033–49. 11 Collier GR, McMillan JS, Windmill, et al. Becaon: a novel gene involved in the regulation of energy balance. Diabetes 2000; 49: 1766–71. 12 Reue K, Péterfy M. Mouse models of lipodystrophy. Curr Atheroscl Rep 2000; 2: 390–96. 13 Panz VR, Wing JR, Raal FJ, Kedda M-A, Joffe BI. Improved glucose tolerance after effec...
متن کاملDehydroepiandrosterone: is there a role for replacement?
Dehydroepiandrosterone (DHEA) and its sulfated ester are found in high concentrations in the plasma; however, their role in normal human physiology, other than as precursors for sex hormones, remains incompletely defined. Studies of rodent models have shown that these hormones have beneficial effects on a wide variety of conditions, such as diabetes, obesity, immune function, atherosclerosis, a...
متن کاملDehydroepiandrosterone replacement therapy in older adults: 1- and 2-y effects on bone.
BACKGROUND Age-related reductions in serum dehydroepiandrosterone (DHEA) concentrations may be involved in bone mineral density (BMD) losses. OBJECTIVE The objective was to determine whether DHEA supplementation in older adults improves BMD when co-administered with vitamin D and calcium. DESIGN In year 1, a randomized trial was conducted in which men (n = 55) and women (n = 58) aged 65-75 ...
متن کاملEffect of 12-month dehydroepiandrosterone replacement therapy on bone, vagina, and endometrium in postmenopausal women.
The effect of 12-month dehydroepiandrosterone (DHEA) replacement therapy has been evaluated in 14 60- to 70-yr-old women who received daily applications of a 10% DHEA cream. Vaginal epithelium maturation was stimulated by DHEA administration in 8 of 10 women who had a maturation value of zero at the onset of therapy, whereas a stimulatory effect was also seen in all three women who had an inter...
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ژورنال
عنوان ژورنال: European Journal of Endocrinology
سال: 2001
ISSN: 0804-4643,1479-683X
DOI: 10.1530/eje.0.1450103